Addiction Medicine

Ghrelin and glucagon-like peptide studied, role of cannabinoids revealed

Published in Women's Health Weekly, January 27th, 2005

According to recent research from Begium published in the British Journal of Nutrition, plasma ghrelin and a glucagon-like peptide may be modulated by two anorexigenic cannabinoid compounds.

"The CB1 cannabinoid receptor antagonist, N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxamide (Rimonabant; SR141716A), and oleoylethanolamide (OEA) are known to reduce food consumption, by, at least partially, a peripheral regulation of feeding. The effects of systemic SR141716A or OEA (5 mg/kg) administrations on food consumption in 24 h food-deprived and fed rats were investigated.

"In fasted rats, SR141716A and OEA...

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Source: Women's Health Weekly (2005-01-27)

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