Women's Health Weekly
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Breast Cancer
Ectopic IRF-1 expression promotes tumor cell death
February 3rd, 2005
Ectopic IRF-1 expression promotes apoptosis in breast tumor cells. "The overexpression of the inhibitor of apoptosis protein, survivin, may provide tumor cells with a distinct survival advantage in situ; hence, therapeutic strategies have been designed to inhibit its expression," oncologists in the United States explained. In a recent study, E. Pizzoferrato and coauthors at the University of Pittsburgh "ectopically expressed the interferon regulatory factor (IRF)-1 protein in the breast carcinoma cell lines MDA-MB-468 and SK-BR-3 using a recombinant adenovirus (Ad-IRF-1)." "By screening microarray analysis of cDNA from the human...
Source: Women's Health Weekly (2005-02-03)
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