Women's Health Weekly
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Breast Cancer
Loss of ERalpha signaling induces epigenetic silencing of downstream targets
February 3rd, 2005
Loss of estrogen receptor (ER) signaling induces epigenetic silencing of downstream targets in breast cancer. "Alterations in histones, chromatin-related proteins, and DNA methylation contribute to transcriptional silencing in cancer, but the sequence of these molecular events is not well understood," researchers in the United States explained. In a recent study, Y.W. Leu and coauthors at Ohio State University found that, after disruption of ERalpha signaling "by small interfering RNA, polycomb repressors and histone deacetylases are recruited to initiate stable repression of the progesterone receptor (PR) gene, a known ERalpha target,...
Source: Women's Health Weekly (2005-02-03)
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