Women's Health Weekly
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Breast Cancer
Mammaglobin-1 promoter enhances the transfection of mammary tumor cells
February 3rd, 2005
Mammaglobin-1 promoter enhances the transfection of mammary tumor cells. According to recent research from Canada, "expression of secretoglobin family 2A member 2 (SCGB2A2, also known as mammaglobin-1) has been detected in a high percentage of primary and metastatic breast tumors, to a lesser extent in normal breast, but not in other normal tissues." "Plasmid transfection studies in our lab and others, however, were unable to identify the genetic elements regulating this specificity. Here we demonstrate that a 25-kb DNA fragment derived from the human SCGB2A2 gene upstream of the protein coding sequence was highly active and preferentially expressed...
Source: Women's Health Weekly (2005-02-03)
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