Women's Health Weekly
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Breast Cancer Vaccine
Vaccine against epidermal growth factor receptor useful for breast cancer
February 3rd, 2005
Vaccination against mutated epidermal growth factor receptor may boost immune responses against breast cancer. "Mutated epidermal growth factor receptor (EGF-RvIII, DeltaEGF-R, and de2-7 EGF-R) is the result of an 801-bp deletion within the extracellular domain of wild-type EGF-R and is expressed by breast carcinomas, but not by normal breast tissues. EGF-RvIII is expressed both on the surface and in the cytoplasm of tumor cells. Thus, EGF-RvIII is a potential tumor-specific target for both antibodies and T cells. However, it is not known whether breast cancer patients can raise immune responses to EGF-RvIII expressed by their tumors. The demonstration of...
Source: Women's Health Weekly (2005-02-03)
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