Women's Health Weekly
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Cardiology
SERMs prevent neointima formation in ovariectomized rats after vascular injury
February 3rd, 2005
Selective estrogen receptor modulators prevent neointima formation in ovariectomized rats after vascular injury, according to researchers in drug design at the University of Helsinki. "Exploitation of estrogen's vasculoprotective properties in drug design is difficult due to its adverse effects on endometrium and breast. Selective estrogen receptor modulators (SERMs) act as estrogen agonists in some tissues but are anti-estrogenic in others. "We investigate here whether tamoxifen, raloxifene, and two novel SERMs, ospemifene and fispemifene, preserve estrogen's beneficial effects on the ovariectomized rat vascular wall, and correlate their effects...
Source: Women's Health Weekly (2005-02-03)
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