Women's Health Weekly
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Cervical Cancer
Estrogen has antiapoptotic effect in cervix separate from mitogenic function
February 3rd, 2005
Estrogen appears to have an antiapoptotic effect in cervical cells independent of its mitogenic function, suggest researchers. Q.F. Wang and colleagues, University Hospitals of Cleveland, Ohio, "investigated the antiapoptotic effects of estrogen in normal and cancerous human cervical cells and the mechanisms involved." They wrote, "Baseline apoptosis in human cervical epithelial cells is mediated predominantly by P2X(7)-receptor-induced, Ca2+-dependent activation of the mitochondrial (caspase-9) pathway. Treatment with 10 nM 17beta-estradiol blocked apoptosis induced by the P2X(7)-receptor ligands ATP and 2',3'-0-(4-benzoylbenzoyl)-ATP in...
Source: Women's Health Weekly (2005-02-03)
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