Women's Health Weekly
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Cervical Cancer
Increased PAI-1 expression correlated with worse survival, relapse
February 3rd, 2005
Increased plasminogen activator inhibitor-1 expression correlates with worse survival and disease relapse in cervical cancer patients, pathologists report. "Cervical carcinoma is a human papillomavirus (HPV)-related immunogenic type of malignancy, in which escape of the tumor from the hosts' immune response is thought to play an important role in carcinogenesis," wrote S. Hazelbag and colleagues, Leiden University, the Netherlands. "The multifunctional cytokine transforming growth factor-beta(1) [TGF-beta(1)] is involved in immunosuppression, stroma and extracellular matrix formation, and controlling (epithelial) cell growth. The plasminogen...
Source: Women's Health Weekly (2005-02-03)
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