Drug Research
Renal and hepatic routes are involved in eliminating palonosetron from the body
Published in Women's Health Weekly, February 3rd, 2005
According to scientists in Switzerland, "Palonosetron (Aloxi, Onicit) is a potent, single stereoisomeric 5-HT3 receptor antagonist developed to prevent chemotherapy-induced nausea and vomiting. The pharmacokinetics and metabolic disposition of a single intravenous [14C]-palonosetron (10 mcg/kg, 0.8 mcCi/kg) bolus dose were evaluated in six healthy volunteers (three males, three females) using serial blood, plasma, urine and fecal samples obtained over 10 days. The safety, tolerability and cardiac...
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