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Women's Health Weekly

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Atherosclerosis



Gender-specific factors modulate atherosclerosis phenotype in rat study



February 10th, 2005

Gender-specific factors modulate atherosclerosis phenotype, results of a study in rats indicate.

"Epidemiological and clinical data demonstrate differences in atherosclerotic coronary heart disease prevalence between age-matched men and premenopausal women. Mechanisms underlying relative athero-susceptibility in men and athero-resistance in premenopausal women remain to be elucidated. Lack of informative animal models hinders research," stated V.L.M. Herrera and colleagues, Boston University.

These researchers have developed "a moderate-expresser line transgenic for human cholesteryl ester transfer protein (CETP) in the Dahl salt-sensitive...


Source: Women's Health Weekly (2005-02-10)

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