Women's Health Weekly
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Breast Cancer
Deficient DNA repair capacity associated with increased cancer risk
February 10th, 2005
Deficiencies in the ability of cells to repair damaged DNA are associated with an increased risk of breast cancer, researchers report. DNA repair is the system of defenses designed to protect the integrity of the genome. Studies have suggested that deficiency in cells' capacity for DNA repair contributes to the accumulation of DNA damage and accelerates the genetic changes involved in carcinogenesis. To evaluate whether reduced DNA repair capacity in the nucleotide excision pathway that fixes DNA alterations known as bulky DNA adducts is associated with breast cancer risk, Regina M. Santella, PhD, of the Columbia University Mailman School of Public...
Source: Women's Health Weekly (2005-02-10)
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