Women's Health Weekly
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Cancer Genetics
Sequence comparison made of primate BRCA1 loci and corresponding proteins
February 10th, 2005
Researchers with the U.S. National Cancer Institute report they've done "the first comprehensive sequence comparison of primate BRCA1 loci and corresponding proteins." "Germ-line mutations in the BRCA1 gene predispose affected individuals to breast and ovarian cancer syndromes. In an attempt to systematically analyze a broader spectrum of genetic changes ranging from frequent exon deletions and duplications to amino acid replacements and protein truncations, we isolated and characterized full size BRCA1 homologues from a representative group of non-human primates," wrote A. Pavlicek and colleagues. "The comparison revealed an unusually high...
Source: Women's Health Weekly (2005-02-10)
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