Women's Health Weekly
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Cancer Therapy
Oncolytic vesicular stomatitis virus localizes in breast cancer cells
February 10th, 2005
Oncolytic vesicular stomatitis virus localizes in breast cancer cells. According to a study from the United States, "vesicular stomatitis virus (VSV) is a candidate for development for cancer therapy. We created a recombinant replicating VSV (rrVSV) with an altered surface protein that targeted preferentially to breast cancer cells. The rrVSV genome contained a single glycoprotein (gp) gene derived from Sindbis virus." "This gene expressed a chimeric Sindbis E2 binding gp and the native Sindbis E1 fusion gp. The chimeric E2 binding gp, called Sindbis-SCA-erbb2, was modified to reduce its native binding function and to contain a single chain antibody...
Source: Women's Health Weekly (2005-02-10)
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