Uterine Cancer

Somatic D-loop mitochondrial DNA mutations frequent in uterine serous carcinoma

Published in Women's Health Weekly, February 17th, 2005

According to recent research published in the European Journal of Cancer, "The mitochondria plays a role in apoptosis. Its genome is also more susceptible to mutations because of high levels of reactive oxygen species and limited repair mechanisms.

"The D-loop of mitochondrial DNA (mtDNA) contains essential transcription and replication elements, and mutations in this region might alter the rate of DNA replication."

Study author T. Pejovic and colleagues at the Roswell Park Cancer Institute, Buffalo, New York, "examined genetic alterations in the D-loop region of mtDNA in uterine serous carcinoma (USC) samples and their paired normal adjacent...

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Source: Women's Health Weekly (2005-02-17)

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