Women's Health Weekly
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Breast Cancer
ADAM 12 cleaves extracellular matrix proteins, correlates with cancer status
February 17th, 2005
ADAM 12, a member of a family of disintegrin-containing metalloproteases that have been implicated in a variety of diseases including Alzheimer's disease, arthritis, and cancer, according to a U.S. study cleaves to extracellular matrix proteins and correlates with cancer status and stage. "We purified ADAM 12 from the urine of breast cancer patients via Q-Sepharose anion exchange and gelatin-Sepharose affinity chromatography followed by protein identification by matrix-assisted laser desorption/ ionization-time of flight mass spectrometry. Four peptides were identified that spanned the amino acid sequence of ADAM 12," wrote R. Roy and colleagues, Harvard University,...
Source: Women's Health Weekly (2005-02-17)
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