Women's Health Weekly
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Cell Biology
Mammary ECM composition and function are altered by reproductive state
February 17th, 2005
Mammary extracellular matrix composition and function are altered by reproductive state, report University of Colorado medical oncologists. "To address whether reproductive state alters mammary gland extracellular matrix (ECM) composition and function, ECM was isolated from nulliparous, pregnant, lactating, involuting, and regressed rat mammary glands," said P. Schedin and colleagues. "The ECM composition of fibronectin, tenascin, laminin, clusterin, and matrix metalloproteinases (MMPs) was found to vary dramatically with reproductive state. In 3-dimensional (3-D) culture, we identified novel effects of these endogenous mammary matrices on mammary...
Source: Women's Health Weekly (2005-02-17)
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