Women's Health Weekly
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Breast Cancer
Aurora A Ile/Ile genotype significantly associated with breast cancer risk
February 24th, 2005
The Aurora A Ile/Ile genotype is significantly associated with an increased breast cancer risk. According to a study from China, "Aurora-A/BTAK/STK15, involved in regulating centrosomes and chromosome segregation, is overexpressed in human breast carcinoma and other cancers. "The Phe31->Ile polymorphism in Aurora A alters the kinase function, with the Ile31 variant being preferentially amplified and associated with degree of aneuploidy in human tumors." "We have previously shown that the Phe31Ile polymorphism is associated with the occurrence and advanced disease status of esophageal cancer. This case-control study examined the...
Source: Women's Health Weekly (2005-02-24)
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