Women's Health Weekly
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Breast Cancer
Cytologic tumor smears provide suitable CISH samples
February 24th, 2005
Cytologic smears of breast tumor tissue provide specimens suitable for CISH analysis. "The current use of humanized monoclonal antibody trastuzumab for the treatment of patients with metastatic breast cancer has made evaluation of HER-2/neu status an important clinical issue," pathologists in South Korea explained. "Chromogenic in situ hybridization (CISH), in which the DNA probe is detected with an immunohistochemistry (IHC)-like peroxidase reaction, has been recently developed for the assessment of HER-2/neu status in formalin-fixed breast cancer specimens." In a recent study, G.Y. Kim and coauthors at Sungkyunkwan University "applied...
Source: Women's Health Weekly (2005-02-24)
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