Women's Health Weekly
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Human Papillomavirus
HPV associated with genomic instability
February 24th, 2005
High risk human papillomavirus (HPV) is associated with genomic instability. A. Alazawi and colleagues at the Hutchison MRC Research Center recently reported, "Host genomic abnormalities may determine the natural history of cervical squamous intraepithelial lesions (SILs). We undertook comparative genomic hybridization analysis of epithelium carefully microdissected from 70 cervical SILs, the largest series to date." "In contrast to previous studies, we used frozen sections for optimal DNA quality and examined whether patterns of DNA copy number imbalance (CNI) are characteristic of SIL grade, HPV status, and postoperative recurrence," the...
Source: Women's Health Weekly (2005-02-24)
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