Women's Health Weekly
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Cardiac Hypertrophy
Normal cardiac growth may be cofactor in development of genetic cardiomyopathies
February 24th, 2005
Physiological growth synergizes with pathological genes in experimental cardiomyopathy. According to recent research published in the journal Circulation Research, "Hundreds of signaling molecules have been assigned critical roles in the pathogenesis of myocardial hypertrophy and heart failure based on cardiac phenotypes from alpha-myosin heavy chain - directed overexpression mice. Because permanent ventricular transgene expression in this system begins during a period of rapid physiological neonatal growth, resulting phenotypes are the combined consequences of transgene effects and normal trophic influences." F. Syed and colleagues of the...
Source: Women's Health Weekly (2005-02-24)
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