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Breast Cancer

Breast carcinoma cell line is resistant to DNA-damaging drugs

According to a study from Russia, "To investigate the phenomenon of active dissociation of the vital dye, Hoechst 33342 (Ho342), from DNA (DNA clearing), a new MCF7HoeR-7 human breast carcinoma cell line was isolated from parent MCF7 cells by step-wise selection with increasing concentrations of Ho342."

"This cell line possesses an enhanced ability for DNA clearing. The MCF7HoeR-7 line is characterized in detail and compared with the parental MCF7 line and a typical P-glycoprotein-mediated multidrug resistant (MDR) cell line, MCF7/Adr," V.V. Levina and colleagues reported.

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