Women's Health Weekly
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Contraception
Combined OC/HIV association may be due to CCR5 upregulation on lymphocytes
March 3rd, 2005
According to recent research from England, "Combined oral contraceptives may alter the microenvironment of the female genital tract and, thus, influence susceptibility of endocervical cells to HIV-1 transmission." M. Prakash and colleagues, Northwick Park Hospital & Clinical Research Center, Imperial College of Science Technology & Medicine, Middlesex, UK, said, "The mechanism for this effect is unknown but might involve combined oral contraceptive up-regulation of chemokine receptors on CD4+ endocervical cells." Pursuing this hypothesis, they "measured chemokine co-receptor (CCR5 and CXCR4) expression on cervical intraepithelial CD4+ T lymphocytes,...
Source: Women's Health Weekly (2005-03-03)
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