Women's Health Weekly
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Breast Cancer
STK15 gene implicated in carcinogenesis
March 10th, 2005
A study from Vanderbilt University has provided additional evidence implicating the STK15 gene in the development of breast cancer. "STK15 is a member of a family of serine/threonine kinases that act as key regulators of chromosome segregation and cytokinesis. Overexpression of the STK15 gene leads to centrosome amplification, chromosomal instability, aneuploidy, and transformation. It has been reported that the 91T -> A (Phe -> Ile at codon 31) polymorphism in the STK15 gene affects the function of this gene," wrote Q. Dai and colleagues. "We hypothesized that this polymorphism may interact with endogenous estrogen exposure in the risk of...
Source: Women's Health Weekly (2005-03-10)
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