Women's Health Weekly
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Breast Cancer
Candidate genes in breast tumors identified through matrix-CGH analysis
March 17th, 2005
A number of candidate genes in breast cancer have been identified through matrix-CGH analysis. In a recent study from Germany, "[g]enomic imbalances in 31 formalin-fixed and paraffin-embedded primary tumors of advanced breast cancer were analyzed by microarray-based comparative genomic hybridization (matrix-CGH)." "A DNA chip was designed comprising 422 mapped genomic sequences including 47 proto-oncogenes, 15 tumor suppressor genes, as well as frequently imbalanced chromosomal regions," explained M. Nessling and coauthors at the Deutsches Krebsforschungszentrum in Heidelberg. "Analysis of the data was challenging due to the impaired quality of DNA...
Source: Women's Health Weekly (2005-03-17)
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