Women's Health Weekly
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Breast Cancer
Endothelin-1 increases breast tumor perfusion in rats
March 17th, 2005
Endothelin-1 (ET-1) increases breast tumor blood flow in rats. ET-1 "causes vasodilatation via its endothelin-B receptors," scientists in the United States explained. "ET-1, endothelin-3 and endothelin-B receptors are known to be overexpressed in breast carcinoma tissue." "However, the functional role of ET-1 in tumor vasculature is still unknown," noted A. Gulati and colleagues at the University of Illinois. "If ET-1 causes an increase in breast tumor perfusion, it could be used to increase delivery of chemotherapeutic agents to the tumor tissues." In a study conducted by Gulati and collaborators, "[f]emale Sprague-Dawley rats...
Source: Women's Health Weekly (2005-03-17)
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