Women's Health Weekly
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Breast Cancer
Estrogen mediates genetic factors associated with breast cancer in female rats
March 17th, 2005
According to a study from the United States, "Estrogens play a crucial role in the causation and development of sporadic human breast cancer (BC)." "Chromosomal instability (CIN) is a defining trait of early human ductal carcinoma in situ (DCIS) and is believed to precipitate breast oncogenesis. We reported earlier that 100% of female ACI (August/Copenhagen/Irish) rats treated with essentially physiological serum levels of 17beta-estradiol lead to mammary gland tumors with histopathologic, cellular, molecular, and ploidy changes remarkably similar to those seen in human DCIS and invasive sporadic ductal BC," wrote J.J. Li and colleagues, University of Kansas. ...
Source: Women's Health Weekly (2005-03-17)
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