Cancer Diagnostics

Markers distinguish primary ovarian tumors from metastatic colorectal cancer

Published in Women's Health Weekly, March 17th, 2005

Three immunohistochemical markers expressed in colonic adenocarcinoma help differentiate ovarian tumors from metastatic colorectal cancer, Emory University Hospital pathologists report.

"Distinguishing primary ovarian carcinoma, particularly endometrioid and mucinous subtypes, from metastatic colorectal carcinoma to the ovary is often difficult on histologic examination alone. Recently, three immunohistochemical markers - CDX2, a homeobox gene encoding an intestine-specific transcription factor; alpha-methylacyl-CoA racemase (AMACR/P504S), a mitochondrial and peroxisomal enzyme with fairly restricted expression in selective tumors; and beta-catenin, an adenomatous...

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Source: Women's Health Weekly (2005-03-17)

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