Women's Health Weekly
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Cancer Metastasis
Tight junction protein levels decline in metastatic breast cancers
March 17th, 2005
Tight junction protein levels decline in metastatic breast cancers. According to recent research published in the European Journal of Cancer, "the aim of this study was to investigate the expression of Zonula Occludens (ZO) proteins ZO-1, ZO-2 and ZO-3, and MUPP-1 (multi-PDZ domain protein 1), peripheral/plaque proteins that function in maintaining tight junction integrity and in transducing regulatory signaling events in patients with primary breast cancer." "Breast cancer primary tumors (n=114) and background tissues (n=30) were processed for quantitative-polymerase chain reaction (PCR) analysis, Western blotting and immunostaining....
Source: Women's Health Weekly (2005-03-17)
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