Women's Health Weekly
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Cancer Therapy
Novel breast cancer cell line may aid research on trastuzumab resistance
March 17th, 2005
A novel breast cancer cell line may facilitate research on trastuzumab resistance. "Clinical resistance to the HER-2 oncogene-targeting drug trastuzumab (Herceptin) exists, but studies of the resistance mechanisms are hampered by the lack of suitable experimental model systems," oncologists in Finland explained. In their study, M. Tanner and coauthors at the University of Tampere "established a carcinoma cell line (designated JIMT-1) from a pleural metastasis of a 62-year old patient with breast cancer who was clinically resistant to trastuzumab." "JIMT-1 cells grow as an adherent monolayer and form xenograft tumors in nude...
Source: Women's Health Weekly (2005-03-17)
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