Women's Health Weekly
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Cardiovascular Research
Study finds CV modeling responses to presence of 3 copies of mouse chromosome 16
March 17th, 2005
Researchers have investigated the effects of genetic background on cardiovascular anomalies in the Ts16 mouse. According to scientists in the United States, "To investigate the genetic contribution to phenotypic variability in aneuploidy, we generated mice with trisomy 16 (Ts16) by mating [Rb(6.16)24Lub x Rb(16.17)7Bnr]F1 males with females from four inbred strains, BALB/cJ, C3H/HeJ, C57BL/6J, and DBA/2J." A.J. Villar and colleagues of the University of California in San Francisco reported, "Among the four Ts16 strains that were generated, there were no significant differences in survival, weight, or length relative to euploid control littermates at...
Source: Women's Health Weekly (2005-03-17)
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