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Endometriosis

Distinct regulation of COX-2 gene by IL-1beta may play pathophysiologic role

Published in Women's Health Weekly, March 17th, 2005

A study from Taiwan suggests that distinct regulation of the cyclooxygenase-2 gene by interleukin (IL)-1beta may play pathophysiologic role in endometriosis.

M.H. Wu and colleagues, National Cheng Kung University, wrote, "Aberrant production of cyclooxygenase-2 (COX-2) plays pivotal roles in many pathological processes including tumorigenesis and endometriosis, although the underlying mechanism remains obscure."

In their study they presented "evidence to demonstrate that COX-2 is distinctly regulated by IL-1beta in normal and endometriotic stroma."

According to Wu and coworkers, "Ectopic endometriotic stromal cell is at least 100...

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