Women's Health Weekly
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Cancer Genetics
Recent findings illuminate research in cancer genetics
March 24th, 2005
Investigators in the United Kingdom and United States have published new cancer genetics data. Study 1: University of Oxford members of the Structural Genome Consortium have described the nuclear magnetic resonance (NMR) structure of the C-terminal BRCT domain of the BRCA1 gene. "BRCA1 is a tumor suppressor protein associated with breast and ovarian cancer. The C-terminal region of BRCA1 consists of two closely spaced BRCT domains which mediate essential biological functions, including regulation of transcription and control of cell-cycle progression by their interaction with phosphorylated effector proteins. Here we report the NMR structure of the...
Source: Women's Health Weekly (2005-03-24)
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