Ovarian Cancer

ApoE required for cell proliferation, survival in apoE-expressing cancer cells

Published in Women's Health Weekly, March 24th, 2005

According to a study from the Johns Hopkins Medical Institutes, "Apolipoprotein E (ApoE) has been recently identified as a potential tumor-associated marker in ovarian cancer by serial analysis of gene expression.

"ApoE has long been known to play a key role in lipid transport, and its specific isoforms may participate in atherosclerogenesis. However, its role in human cancer is not known," wrote Y.C. Chen and colleagues.

In their research they observed that "apoE expression was frequently detected in ovarian serous carcinomas, the most common and lethal type of ovarian cancer. It was not detected in serous borderline tumors and normal ovarian...

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Source: Women's Health Weekly (2005-03-24)

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