Published in Women's Health Weekly, March 24th, 2005
According to a study from the United States, "the potential for reproductive toxicity of an antisense oligonucleotide designed to inhibit ICAM-1 was evaluated as part of the safety assessment for this compound. The human active ICAM-1 inhibitor (ISIS 2302) is not pharmacologically active in rabbits. Female rabbits were treated once daily on day 6 through 18 of gestation."
"Rabbits were treated with 0, 1, 3, and 9 mg/kg ISIS 2302 by daily i.v injection. Reproductive indices evaluated included estrus cycling, litter parameters, fetal development, and fetal body weight....
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