Drug Development
Antisense blockade of ICAM-1 does not harm fetal development in study models
Published in Women's Health Weekly, March 24th, 2005
According to a study from the United States, "the potential for reproductive toxicity of an antisense oligonucleotide designed to inhibit ICAM-1 was evaluated as part of the safety assessment for this compound. The human active ICAM-1 inhibitor (ISIS 2302) is not pharmacologically active in rabbits. Female rabbits were treated once daily on day 6 through 18 of gestation."
"Rabbits were treated with 0, 1, 3, and 9 mg/kg ISIS 2302 by daily i.v injection. Reproductive indices evaluated included estrus cycling, litter parameters, fetal development, and fetal body weight....
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Women's Health Weekly
More Articles from Women's Health Weekly
- Atherosclerosis Progression
Lack of social support associated with faster progression of CAD in women - Breast Cancer
Short course of hCG may have chemoprotective potential - Coronary Artery Bypass Surgery
Gender a factor in who gets bypass surgery - Disease Prevention
Patients active in their healthcare may lower heart disease risk - Obstetrics
Pregnancy weight gain guidelines are not being followed in U.S. - Abortion
Abortion issue flares in health hearing - More from this issue of Women's Health Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
