Women's Health Weekly
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Breast Cancer
Breast cancer resistance protein gene expression modulated using siRNAs
March 31st, 2005
Breast cancer resistance protein gene expression is modulated using small interfering RNAs. According to recent research published in the journal Molecular Cancer Therapeutics, "Overexpression of the breast cancer resistance protein (BCRP/ABCG2) confers multidrug resistance (MDR) to tumor cells and often limits the efficacy of chemotherapy. "To circumvent BCRP-mediated MDR, a common approach is the use of potent and specific inhibitors of BCRP transport such as fumitremorgin C, novobiocin, and GF 120918. Here, we evaluated a new approach using RNA interference for the specific knockdown of BCRP." "We designed and...
Source: Women's Health Weekly (2005-03-31)
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