Women's Health Weekly
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Breast Cancer
ERCC2 genotypes and corresponding haplotype linked with breast cancer risk
March 31st, 2005
ERCC2 genotypes and a corresponding haplotype are linked with breast cancer risk. "The polygenic concept of breast cancer susceptibility calls for the identification of genetic variants that contribute to breast cancer risk. Reduced DNA repair proficiencies in women with breast cancer pointed to a possible role of DNA repair enzymes in the risk to develop the disease. "The nucleotide excision repair enzyme encoded by the excision repair cross-complementing group 2 gene ERCC2 (formerly XPD) known to cause skin cancer by germ line mutations has multiple regulatory cellular functions, including nucleotide excision repair, basal transcription, cell cycle...
Source: Women's Health Weekly (2005-03-31)
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