Women's Health Weekly
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Breast Cancer
Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing
March 31st, 2005
Breast cancer researchers at the U.S. National Cancer Institute have shown that parity-induced mammary epithelial cells in mice are pluripotent, self-renewing, and are sensitive to tumor growth factor (TGF)-beta1 expression. C.A. Boulanger and colleagues wrote, "A parity-induced mammary population, marked by beta-galactosidase expression conditionally activated through cre-lox recombinase, originates in WAP-Cre/Rosa-lox-STOP-lox-LacZ (WAP-Cre/Rosa-LacZ) female mice during pregnancy, lactation, and involution. During subsequent pregnancies, these parity-induced mammary epithelial cells (PI-MEC) proliferated to produce new secretory acini composed of secretory luminal...
Source: Women's Health Weekly (2005-03-31)
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