Women's Health Weekly
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Breast Cancer
XPD polymorphism increases breast cancer risk from PAH-DNA adducts/cigarettes
March 31st, 2005
An XPD gene polymorphism increases the risk of breast cancer from PAH-DNA adducts and cigarette smoking. "DNA repair is essential to an individual's ability to respond to damage caused by environmental carcinogens. Alterations in DNA repair genes may affect cancer risk by influencing individual susceptibility to environmental exposures. "XPD, a gene involved in nucleotide excision repair, may influence individual DNA repair capacity particularly of bulky adducts," investigators in the United States report. "Using a population-based breast cancer case-control study that was specifically conducted to examine markers of environmental...
Source: Women's Health Weekly (2005-03-31)
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