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Endometriosis

Biopharmaceutical company announces positive endometriosis trial results

Published in Women's Health Weekly, March 31st, 2005

Neurocrine Biosciences, Inc., (NBIX) announced positive results from the company's phase I clinical trial with its proprietary, orally active small molecule Gonadotropin-Releasing Hormone (GnRH) receptor antagonist.

The trial was designed to evaluate the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of two dose levels of NBI-56418 given once daily for 6 weeks in 60 healthy premenopausal women. The study demonstrated that NBI-56418 was safe and well tolerated. NBI-56418 demonstrated a dose-dependent suppression of estradiol that was observed throughout the duration of dosing.

The study was a double-blind, placebo-controlled trial involving...

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