Women's Health Weekly
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Breast Cancer
Reduced PTEN expression predicts relapse in patients treated with tamoxifen
April 7th, 2005
Reduced expression of the PTEN gene is predictive of relapse in breast cancer patients treated with tamoxifen, researchers have found. "Tamoxifen treatment substantially improves the 10-year survival of women with estrogen-receptor (ER)-alpha positive tumors. However, approximately one-third of all breast cancer patients with ER-alpha positive tumors progress on antiestrogen therapy. The molecular mechanism(s) involved in antiestrogen-resistant phenotype of breast carcinoma is not completely understood," said N. Shoman and colleagues, University of Saskatchewan, Royal University Hospital. "The PTEN (phosphatase and tensin homolog deleted on...
Source: Women's Health Weekly (2005-04-07)
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