Women's Health Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Women's Health Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Breast Cancer Therapy
Arg-482 not essential for transporting antibiotics, bile acids, and sterols
April 7th, 2005
Arginine-482 may not be essential for transporting antibiotics, primary bile acids, and unconjugated sterols by the human breast cancer resistance protein. "The human BCRP (breast cancer resistance protein, also known as ABCG2) is an ABC (ATP-binding cassette) transporter that extrudes various anticancer drugs from cells, causing multidrug resistance. To study the molecular determinants of drug specificity of BCRP in more detail, we have expressed wild-type BCRP (BCRP-R) and the drug-selected cancer cell line-associated R482G (Arg(482)->Gly) mutant BCRP (BCRP-G) in Lactococcus lactis," scientists in England reported. "Drug resistance and...
Source: Women's Health Weekly (2005-04-07)
|
