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Breast Cancer Vaccine

DNA vaccine inhibits breast cancer in mice through induction of autoimmunity

According to a study from Italy, "Plasmid DNA vectors encoding the full-length (VR1012/HER-2-FL) or only the extracellular and transmembrane domains (VR1012/HER-2-ECD-TM) of human (h) HER-2/neu protooncogene were used to vaccinate HER-2/neu transgenic mice (N202) engineered to overexpress the rat (r) neu protooncogene product (r-p185^neu). Both the full-length and the deleted vaccines were significantly (p=0.0001 and p=0.06, respectively) more active than the empty-vector (VR1012/EV) in preventing and delaying HER-2/neu-driven...

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