Women's Health Weekly
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Cancer Genetics
BRCA1 and BRCA2 breast tumor development pathways may differ
April 7th, 2005
A study from the Netherlands suggests that breast tumor development pathways may differ between BRCA1- and BRCA2-related cancers. "BRCA1 or BRCA2 germline mutations cause [about] 30% of breast cancers within high-risk families. This represents 5% of total breast cancer incidence. Although BRCA1 and BRCA2 are both implicated in DNA repair and genome stability, it is unknown whether BRCA1 and BRCA2 are associated with similar or distinct diseases," said E.H. van Beers and colleagues at the Netherlands Cancer Institute, Amsterdam. "In a previous study we reported that BRCA1-related breast carcinomas show a distinct genomic profile as determined by...
Source: Women's Health Weekly (2005-04-07)
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