Women's Health Weekly
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Cancer Vaccine
Role of exosomes in cancer-associated T-cell signaling defects investigated
April 7th, 2005
Researchers report the results of a study on the role of tumor-derived exosomes in cancer-associated T-cell signaling defects in a recent issue of the British Journal of Cancer. "Dendritic and lymphoid exosomes regulate immune activation. Tumors release membranous material mimicking these exosomes, resulting in deletion of reactive lymphocytes. Tumor-derived exosomes have recently been explored as vaccines, without analysis of their immunologic consequences. This investigation examines the composition of tumor-derived exosomes and their effects on T lymphocytes. Membranous materials were isolated from ascites of ovarian cancer patients (n=6) and Western...
Source: Women's Health Weekly (2005-04-07)
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