Women's Health Weekly
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Cardiology
Report describes methods used to generate HSP70 transgenic mice
April 7th, 2005
A recent report describes the use of transgenic mice to study cytoprotection by the stress proteins. According to recent research published in the journal Methods, "Heat shock or stress proteins (HSPs) have been shown to be able to confer cytoprotection in a diversity of cell types and organisms. We were interested in assessing if HSPs, in particular HSP70, were protective against pathophysiological stresses such as myocardial ischemia." R. Mestril of Loyola University explained, "Our approach was to generate a transgenic mouse line that would constitutively express high levels of an inducible rat HSP70 isoform in the heart. The hearts of the...
Source: Women's Health Weekly (2005-04-07)
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