Women's Health Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Women's Health Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Cell Biology
Select signaling pathways could be targeted for breast cancer inhibition
April 7th, 2005
Select signaling pathways could be targeted for breast cancer inhibition. "We evaluated the signaling pathways involved in regulating vascular endothelial growth factor (VEGF), a potent angiogenic growth factor, in response to natural and synthetic progestins in breast cancer cells. Inhibition of the phosphoinositide-3'-kinase (PI3-kinase) signaling pathway or the specificity protein-1 (SP-1) transcription factor abolished both progesterone- and medroxyprogesterone acetate (MPA)-induced VEGF secretion from BT-474 and T47-D-CO cells," scientists in the United States report. "Inhibitors of the MAPK kinase 1/2/MAPK and N-terminal jun kinase/MAPK...
Source: Women's Health Weekly (2005-04-07)
|
