Women's Health Weekly
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Biological Therapies
Enamel matrix derivative inhibited breast cancer cell attachment to bone
April 14th, 2005
Enamel matrix derivative (EMD) might be a potent inhibitor and anti-adhesive agent against breast cancer cell attachment to bone. "This study examined whether EMD inhibits the adhesion of cancer cells to bone. A typical breast cancer cell line, MCF-7, was used. Conditioned human osteosarcoma cell (Saos-2) medium was used as extracellular bone matrix (ECBM) to measure cell attachment," scientists in Japan reported. "MCF-7 cells were incubated on ECBM-coated culture plates with or without soluble EMD, Arg-Gly-Asp (RGD) sequence blocking peptides, recombinant bone sialoprotein (rBSP), or specific integrin antibodies, and the attached cells were...
Source: Women's Health Weekly (2005-04-14)
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