Women's Health Weekly
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Breast Cancer
5F 203 induces NF-kappa B activity in drug-sensitive breast cancer MCF-7 cells
April 14th, 2005
5F 203 (2-(4-Amino-3-methylphenyl)-5-fluoro-benzothiazole) induces NF-kappa B activity in drug-sensitive human breast cancer MCF-7 cells. According to recent research from the United States, "5F 203 potently inhibits MCF-7 breast cancer cell growth in part by activating the aryl hydrocarbon receptor (AhR) signaling pathway. Ligands for the AhR (i.e. dioxin) have also been shown to modulate the NF-kappaB signaling cascade, affecting physiological processes such as cellular immunity, inflammation, proliferation and survival." "The objective of this study was to investigate the effect of 5F 203 treatment on the NF-kappaB signaling pathway in breast...
Source: Women's Health Weekly (2005-04-14)
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