Women's Health Weekly
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Breast Cancer
Array-CGH and tissue microarrays together help identify prognostic markers
April 14th, 2005
Complimentary use of array-CGH (comparative genomic hybridization) and tissue microarrays can help identify prognostic markers in breast cancer cases, suggest oncologists. "Gene amplification, an important mechanism of oncogene activation in breast cancer, can have both prognostic and therapeutic implications. In this work, an attempt is made to identify amplified genes that can be used to improve prognostication in breast cancer," said G. Callagy and colleagues, University of Cambridge, U.K. They screened "a series of 52 node-negative tumors ...for genomic gains at 57 loci by array CGH. A subset of these genes was identified that could divide the...
Source: Women's Health Weekly (2005-04-14)
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