Women's Health Weekly
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Breast Cancer
Interleukin-1beta induces IL-8 mRNA stabilization in breast cancer cells
April 14th, 2005
Interleukin-1beta induces IL-8 mRNA stabilization in breast cancer cells. According to recent research published in the International Journal of Cancer, "IL-8 plays an integral role in promoting the malignant phenotype in breast cancer, and its production is directly influenced by inflammatory cytokines in the tumor microenvironment. "Here, we show that activation of IL-1beta receptors on malignant HS578t and MDA-MB-231 breast cancer cells strongly induces IL-8 expression and that RNA stabilization is persistently activated at least 12-24 hr after stimulation. SB 203580 and rapamycin reversed the RNA stabilization effect of IL-1beta in a...
Source: Women's Health Weekly (2005-04-14)
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